To understand where I'm coming from - and the sports blogger who tackled this issue just last week we need to delve into the study of chronobiology. To be overtly concise: many aspects of exercise performance suffer in the morning. This has no bearing on the bender you just finished over the weekend and now find yourself curled around the coffee pot in the office all day on Monday. It's actually far more elegant than the simple cause and effect relationship you may have built with Anheuser-Busch. In fact many biological functions relevant to physical performance follow the core body temperature cycle, which is found to be lowest in the morning of an individuals circadian rhythm, and peaks in the early evening.
So you might be asking at this point - how does this relate to a players performance in a football game? "For example, every 0.1℉ decrease in core body temperature results in a nerve conduction velocity decrease of 0.432 m/sec, directly reducing reaction time." While the visiting players themselves may just owe certain aspects of this phenomena to having a bad day, they truly are unable to react with the same level of speed that they could if playing in a home game. We can actually derive statistically significant results from looking at the outcomes of such games and observing various characteristics that may have led to such an outcome.
Knowing what we have learned in our biostats class this semester, the statistically significant difference in win percentage (P = 0.002) certainly did not happen by accident. Looking at this data we come to the indisputable conclusion: teams playing a morning body clock start time face a significant competitive disadvantage. Luckily for the fans, most of the desirable match ups to watch get scheduled for primetime games starting at 4:15 or 8:30 PM. Obviously the NFL does this to garner the highest viewer ratings possible but they also inadvertently ensure prime performances between some of the best rivalries football has to offer. In closing since these statistics were taken over the 2000-2015 season I see it fit to take a moment to honor one of football's greatest quarterbacks to ever take the turf.